Energy Drinks Case

A Can of Bull? Do Energy Drinks Really Provide a Source of Energy?

by Merle Heidemann, Division of Science and Mathematics Education, Michigan State University

Gerald Urquhart, Lyman Briggs School of Science, Michigan State University

Objectives • Describe and categorize chemically the components of various popular “energy drinks.” • Determine the physiological role of these components in the human body. • Explain scientifically how the marketing claims for these drinks are supported (or not). • Determine under what conditions each of the “energy drinks” might be useful to the consumer.

The Case After spending several years working the Sport’s Desk of the Lansing State Journal, Rhonda had landed the job of her dreams as a writer for Runners’ World magazine. Te job was fantastic! Since high school, where she had excelled in cross country, Rhonda had been a consistent runner, participating in local races and those assigned to her for her job. For her last assignment, she had run and reported on the Leadwood, South Dakota, marathon—it was a blast!

As if reading her mind, her boss Charley walked in just then with a can of XS Citrus Blast® in one hand and a list of several other energy drinks in the other.

“We’ve been getting a lot of inquiries about the different energy drinks on the market, including XS Citrus Blast®. Do you know anything about them?” Charley asked.

“I know that people use them for various reasons,” replied Rhonda. “It seems they’re primarily used by athletes to provide some ‘fuel’ as they practice and compete. Other people use them more casually as a way to become ‘energized.’ Tat’s about all I know.”

“Tat seems to be about all any of us knows,” Charley said.

“For your next assignment,” Charley continued, “I want you to find out what each of the ingredients in these drinks is and what it does for a runner or for a non-athlete. You need to be very accurate in your analysis—determine what each component really does for the body, not what the marketers want you to believe it does. Ten look at the marketing claims of some of these drinks and see if the scientific facts match up to them. Many of our readers are using these drinks with some general notion that they’re helpful, but they’re basing their use of them on no scientific information. I’ve got the marketing claims, a list of ingredients and nutrition facts provided on the cans for consumers, and a short list of questions that should get you started. When you research these, be sure to document all your sources of information, keeping in mind that all resources are not equal. Here’s the information.”

“A Can of Bull?” by Heidemann & Urquhart Page 1

With that, Charley left the office. Rhonda looked over the list. “Guess I’ll have to brush up on my biochemistry. No problem. I’m interested in knowing if my running would be improved by drinking this stuff .”

Rhonda recalled that a food’s calorie content was the simplest reflection of its energy content. Looking at Charley’s list she saw that the different energy drinks contained the following numbers of calories:

Energy Drink Calories: XS Citrus Blast® 8 Red Bull® 110 Sobe Adrenaline Rush® 140 Impulse® 110 For comparison: Coca Cola® (12 oz) 140

“A Can of Bull?” by Heidemann & Urquhart Page 2

Marketing Claims Next, Rhonda perused the marketing claims for each drink:

Red Bull® • Te Red Bull energy drink is a functional product developed especially for periods of increased mental

and physical exertion. • It can be drunk in virtually any situation: at sport, work, study, driving and socializing. • Improves performance, especially during times of increased stress or strain. • Improves concentration and reaction speed. • Stimulates the metabolism.

XS Citrus Blast® • Tere is less than / calorie of sugar in XS Citrus Blast. T is qualifies for the government-approved

statement “No Sugar.” Te 8 calories in XS Citrus Blast are from amino acids and are protein calories that aid your body’s natural metabolic process.

• Most -ounce energy drinks in the market today have over  calories and from  to  grams of sugar, which is a simple carbohydrate. Most 12-ounce non-diet soft drinks have  calories from  grams of sugar. Most .-ounce juice drinks have 80 calories from  grams of sugar.

• Calories from sugar and carbohydrates may increase fat deposits. Simple carbohydrates are also called high glycemic (high sugar) foods. High glycemic foods cause your body to pump insulin to digest the sugar, which sends a message to your body to store calories as fat. Low glycemic foods do not pump insulin to the same degree and aid in your body’s natural metabolism of fat, using your body’s fat resources as fuel. Many experts fear that the epidemic incidence of diabetes in North America today may be significantly contributed to by high-glycemic diets. Te 8 calories in XS Citrus Blast are from amino acids and are protein calories that aid your body’s natural metabolic process.

• XS Citrus Blast uses a proprietary blend of Sucralose, Acesulfame Potassium (Ace K), and fruit essences to give the drinks their great flavor without sugar or empty calories. In fact, the 8 calories in the drink come from the 2 grams of amino acids, which are protein calories.

Sobe Adrenaline Rush® • Tis maximum energy supplement delivers an energy boost with a natural passion fruit fl avor. It’s

lightly carbonated with a clean smooth feel. • Tis maximum energy supplement is fortified with a unique blend of natural energizing elements,

including d-ribose, l-carnitine and taurine. It’s pure, concentrated energy in an .-fl uid-ounce can.

Impulse® • Elevate Your Performance • Impulse Energy Drink contains special supplements to immediately enhance mental and physical

efficiency and give you the energy boost you deserve… replenishing your strength. • Impulse gets its energy from a simple source: nutrients, minerals, and vitamins that occur naturally in the

body and foods we eat. Enjoy: the wake-up power of caffeine, the alertness-inducing properties of taurine, the lift you get from vitamins B6 and B12. Combined with Impulse’s other ingredients, these are known to increase mental focus and physical well being, enhance performance, and accelerate metabolism.

“A Can of Bull?” by Heidemann & Urquhart Page 3

Charley’s List of Questions Rhonda realized that before she could start analyzing the energy drinks, she needed to know the answer to the following question:

When we say that something gives us “energy,” what does that mean? What is a biological defi nition of energy?

After satisfying herself that she had a good definition, she turned to the first set of questions on Charley’s list.

. What is the nature (sugar, amino acid, vitamin, etc.) of each ingredient listed on the cans? . What is the physiological role of each in the human body? . Which ingredients provide energy? . Which ingredients contribute to body repair, i.e., which help build or rebuild muscle tissue?

Rhonda was determined to wade through the confusing labeling of the drinks. For example, XS Citrus Blast® boasted that it had no calories but still provided “energy.” Tat made absolutely no sense based on what Rhonda knew about biological energy! T e first thing she needed to do was sort out the various ingredients on the labels—a task that consumers rarely undertake.

“A Can of Bull?” by Heidemann & Urquhart Page 4

Ingredients & Nutrition Facts As in most labels, listed in order of mass in drinks (highest to lowest).

XS Citrus Blast® • Ingredients: carbonated water, l-taurine, l-glutamine, citric acid, adaptogen blend (eleutherococcus

senticosus, panax ginseng, panax quinquefolium, echinacea purpurea, schisandra, astragalus, and reishi), natural flavors, acesulfame potassium, caffeine, sodium benzoate, potassium sorbate, sucralose, niacin, pantothenic acid, pyridoxine HCL, yellow 5, cyanocobalamin

• Nutrition Facts: serving size: 8.4 fl oz; servings per container: 1; calories: 8; fat: 0g; sodium: 24mg; potassium: 25mg; total carbs: 0g; sugars: 0g; protein: 2g; vitamin B3: ; vitamin B6: 300%; vitamin B5: ; vitamin B12: 4900%

Red Bull® • Ingredients: carbonated water, sucrose, glucose, sodium citrate, taurine, glucuronolactone, caff eine,

inositol, niacin, D-pantothenol, pyridoxine HCL, vitamin B12, artifi cial fl avors, colors • Nutrition Facts: serving size: 8.3 fl oz; servings per container: 1; amount per serving: calories: 110; total

fat: 0g; sodium: 200mg; protein: 0g; total carbohydrates: 28g; sugars: 27g

Sobe Adrenaline Rush® • Ingredients: filtered water, high fructose corn syrup, citric acid, taurine, d-ribose, l-carnitine, natural

flavor, inositol, sodium citrate, ascorbic acid, caffeine, monopotassium phosphate, salt, gum arabic, ester gum, siberian ginseng root extract, pyridoxine hydrochloride, guarana seed extract, caramel color, beta-carotene, folic acid, cyanocobalamin

• Nutrition Facts: serving size: 8.3 fl oz; servings per container: 1; amount per serving: calories: 140; total fat: 0g; sodium: 60mg; protein: 1g; total carbohydrates: 36g; sugars: 34g; taurine: 1000mg; d-ribose: 500mg; l-carnitine: 250mg; inositol: 100mg; siberian ginseng: 50mg; guarana: 50mg

Impulse® • Ingredients: carbonated water, sucrose, taurine, glucuronolactone, caffeine, inositol, niacinimide,

pyridoxine HCL, vitamin C (citric acid), vitamin B12, artifi cial fl avors, colors • Nutrition Facts: serving size: 8.3 fl oz; servings per container: 1; calories: 110; fat: 0g; sodium: 200mg;

total carbs: 28g; sugars: 27g; protein: 1g; niacin: 100%; vitamin B6: 250%; vitamin B12: 80%; pantothenic acid: 50%: vitamin C: 100%

Coca Cola® (for later comparison) • Ingredients: carbonated water, high fructose corn syrup and/or sucrose, phosphoric acid, natural fl avors,

caff eine • Nutrition Facts: serving size: 12 fl oz; servings per container: 1; calories: 140; fat: 0g; total carbs: 38g;

sugars: 38 g; protein: 0 g

“A Can of Bull?” by Heidemann & Urquhart Page 5

Biochemical Information Acesulfame Potassium (Sunett)

• Chemical formula: C4H4KNO4S • What it is: Simple ring structure that resembles glucose • What it does: Artificial sweetener to provide taste.

Aspartame • Chemical formula: C H N O14 18 2 5 • What it is: Dipeptide • What it does: Low calorie artificial sweetener that provides taste.

Caff eine • Chemical formula: C H N O8 10 4 2 • What it is: One of the most widely used psychoactive substances in the world. Caffeine is a mild CNS

stimulant with a transient effect that usually passes within a few hours but varies between individuals. • What it does: Some studies have shown that caffeine may improve memory and reasoning responses

on tests; other studies have shown that ingesting 3-9mg of caffeine one hour before physical activity improves endurance running and cycling in athletes. No adverse effects in humans have been documented.

Citric Acid • Chemical formula: C6H8O7 • What it is: Organic acid • What it does: It is a precursor for the citric acid cycle (Kreb’s Cycle), which is a major pathway in the

cell’s production of chemical energy.

Cyanocobalamin • Chemical formula: C H CoN O P63 88 14 14 • What it is: Synthetic form of Vitamin B-12 • What it does: Important for growth, cell reproduction, blood formation, and protein and tissue

synthesis.

Folic Acid • Chemical formula: C H N O19 19 7 6 • What it is: Vitamin • What it does: Required for metabolism of carbon compounds, nucleic acids, and amino acids.

Fructose • Chemical formula: C6H12O6 • What it is: Simple sugar • What it does: Can be converted into a form for entry into the primary metabolic pathway in which the

chemical energy of its bonds is converted into ATP, the primary “energy” molecule in the body.

Glucose • Chemical formula: C6H12O6 • What it is: Simple sugar • What it does: Enters the primary metabolic pathway in which the chemical energy of its bonds is

converted into ATP, the primary “energy” molecule in the body.

“A Can of Bull?” by Heidemann & Urquhart Page 6

Glucuronolactone • Chemical formula: C6H6O6 • What it is: Simple saccharide (sugar) • What it does: It is a normal human metabolic byproduct formed from glucose. Glucuronolactone is found

in connective tissue in animals. Also regulates formation of glycogen. Small amounts shouldn’t be harmful.

1-Glutamine • Chemical formula: C5H10N2O3 • What it is: Amino acid • What it does: Aids in muscle building and maintenance.

Inositol • Chemical formula: C6H6(OH)6 • What it is: A sugar that is a member of the Vitamin B complex • What it does: Controls cholesterol levels and has potential antioxidant capabilities.

Niacin (nicotinic acid) • Chemical formula: C6H5NO2 • What it is: Water soluble vitamin • What it does: Derivatives such as NADH are required for metabolism. It is said to aid in the synthesis of

amino acids, the subunits of proteins. It has not been directly linked to improving athletic performance.

Niacinamide • Chemical formula: C6H6N2O • What it is: Water soluble vitamin • What it does: See niacin above; both are components of the coenzymes NAD and NADP, important in

the redox reactions of metabolism.

Pantothenic Acid (also known as D-pantothenol) • Chemical formula: C9H17O5N • What it is: Synthetic form of Vitamin B-5 • What it does: Precursor of coenzyme A. Helps you use fats and carbohydrates to make molecules used

for energy. Is involved in more than 100 different metabolic pathways including energy metabolism of carbohydrates, proteins and lipids, and the synthesis of lipids, neurotransmitters, steroid hormones, porphyrins, and hemoglobin. It’s found in a wide array of energy drinks and supplements, but its toxicity has not been evaluated.

Potassium sorbate • Chemical formula: C6H8O2 • What it is: Potassium salt of sorbic acid • What it does: Used to inhibit fungal growth in foods.

Pyridoxine HCL • Chemical formula: C8H11NO3 • What it is: Synthetic form of Vitamin B-6 • What it does: Energy production, efficient metabolic functioning, protein digestion, as well as

maintaining healthy nervous system, skin, hair and nails. Te B-compound vitamins are probably the single most important set of factors needed for proper maintenance of the nervous system as well as proper functioning of the cell and its energy metabolism.

“A Can of Bull?” by Heidemann & Urquhart Page 7

Sucralose (splenda) • Chemical formula: C H O Cl12 19 8 3 • What it is: Derivative of sucrose • What it does: Artificial sweetener to provide taste.

Sucrose • Chemical formula: C H O12 22 11 • What it is: Simple sugar • What it does: Can be converted into a form for entry into the primary metabolic pathway in which the

chemical energy of its bonds is converted into ATP, the primary “energy” molecule in the body.

1-Taurine • Chemical formula: C2H7NO3S • What it is: A non-essential amino acid • What it does: Improved reaction time, concentration, and memory (not proven); essential amino acid

for cats.

Water • Chemical formula: H2O • What it is: A solvent for the other ingredients • What it does: Essential for physiological processes.

“A Can of Bull?” by Heidemann & Urquhart Page 8

Your Task Research each ingredient found in these energy drinks. Tis information can be found in biochemistry and nutrition textbooks. Web sources may provide valuable information, but be critical in their use. Many will make unsubstantiated claims. One that can get you started for basic information is http://www.chemindustry.com. Basic information can also be garnered from http://www.usda.gov/wps/portal/usdahome—click on the “Food and Nutrition” link.

Determine the chemical structure, the type of chemical each is, and the physiological role played by each compound. You should have sufficient information to answer Charley’s list of questions as well as the additional questions listed below. Fill out the table and answer the questions. Please cite any websites that you used in your analysis.

Post Research Analysis Using the information that your group gathered, place each of the ingredients for your drink under the proper heading in the table below.

Sources of Energy Amino Acids Stimulants and Vitamins Other—please categorize

“A Can of Bull?” by Heidemann & Urquhart Page 9

http://www.usda.gov/wps/portal/usdahome�click
http://www.chemindustry.com
Questions . When we say that something gives us “energy,” what does that mean? What is a biological

definition of energy? . What is the physiological role of each of the molecules in your table?

a. Which ingredients provide energy? How do they do that? b. Which ingredients contribute to body repair, i.e., which help build or rebuild muscle tissue?

. In what ways might the one(s) that does (do) not have a metabolic energy source (caff eine) provide the perception of increased energy after consumption?

. How are the ingredients in these drinks helpful to someone expending a lot of energy, e.g., a runner? . Does your analysis substantiate the claim that this is an “energy drink”? If so, what molecules are

the sources of energy? . Could your drink serve different purposes for different consumers? Explain. . What is the normal physiological response to increased intake of sugars? to increased intake of caff eine? . Is there such a thing as a “sugar high”? Explain your answer. . Evaluate, in terms of basic physiology and biochemistry, the statement: A lack of sleep causes a

lack of energy. 10. Are the product claims legitimate? Why?

11. Should you simply buy a can of Coke® rather than one of these energy drinks? Why/why not?

Assessment Individually, or as a group, write an evaluation of the marketing claims for your drink. You may write the evaluation in the form of an article for readers of Runner’s World. Be sure to include answers to the questions above.

Copyright ©  by the National Center for Case Study Teaching in Science. Originally published // at http://www.sciencecases.org/energy_drinks/energy_drinks.asp Please see our usage guidelines, which outline our policy concerning permissible reproduction of this work.

“A Can of Bull?” by Heidemann & Urquhart Page 10

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BIOL 133 Chapter 7-11 Multiple Choice

Question 1 of 10 1.0/ 1.0 Points

What area is not involved with pumping protons to the intermembrane space?

A.complex I

B.complex II

C.complex III

D.complex IV

Question 2 of 10 1.0/ 1.0 Points

NADH and FADH2 are products of

A.chemiosmosis

B.glycolysis

C.oxidation/reduction reactions

D.substrate level phosphorylation

Question 3 of 10 0.0/ 1.0 Points

When has glucose been broken down from its original 6 carbon molecule to 6 molecules of carbon dioxide?

A.oxidation of pyruvate

B.glycolysis

C.when isocitrate is oxidized to α-Ketoglutarate

D.when α-Ketoglutarate is oxidized to Succinyl CoA

E.condensation of acetyle-CoA with oxaloacetate

Question 4 of 10 0.0/ 1.0 Points

In gluconeogenesis, organisms use ATP to make glucose, then in cellular respiration they break down the glucose again to get energy. Why not just store the ATP? (Select all that apply.)

A. ATP does not have high-energy bonds.

B. ATP is not energy dense enough.

C. ATP only has energy after it is activated by glucose.

D. ATP only has energy when it is attached to glucose.

E. ATP is not stable enough.

F. ATP without a cofactor forms crystalline structures.

G. Using glucose directly to power enzymes is more efficient.

Question 5 of 10 0.0/ 1.0 Points

Molecules generated from butter will enter aerobic cellular respiration at

A.glycolysis

B.oxidative phosphorylation

C.pyruvate oxidation

D.Krebs cycle

Question 6 of 10 1.0/ 1.0 Points

What is not a good biological oxidizing agent?

A.

Fe3+

B.

O2

C.NAD+

D.FAD

Question 7 of 10 1.0/ 1.0 Points

What vitamin derivative accepts hydrogen for complex I during ETC?

A.thiamine

B.riboflavin

C.niacin

D.pantothenic acid

Question 8 of 10 1.0/ 1.0 Points

____________ carbon dioxide molecules are given off during three turns of the Krebs cycle?

A.1

B.2

C.3

D.4

E.6

Question 9 of 10 0.0/ 1.0 Points

Removal of NH3 is best described as ____________ .

A.beta oxidation

B.demination

C.lipolysis

D.glycolysis

Question 10 of 10 1.0/ 1.0 Points

Assuming 2 ATPs are produced per FADH2, how many ATPs will be produced in oxidative phosphorylation per glucose molecule?

A.0

B.2

C.4

D.6

Chapter 8- wk 5

Return to Assessment List

Part 1 of 1 – 9.0/ 10.0 Points

Question 1 of 10 1.0/ 1.0 Points

What is the flow of energy in order from source to end?

A.human→sun→grass→cow

B.cow→human→grass→sun

C.sun→grass→cow→human

D.plant→sun→human→cow

Question 2 of 10 1.0/ 1.0 Points

Light-dependent reactions build NADPH and oxygen by ________________ .

A.oxidation

B.reduction

C.oxidation and reduction

Question 3 of 10 1.0/ 1.0 Points

The light independent reactions are important because they

A.make ATP and NADPH

B.convert CO2 into glucose

C.split H2O to harvest electrons

D.release O2

Question 4 of 10 1.0/ 1.0 Points

P700 first transfers an electron through chlorophyll and a bound

A.quinone

B.ferredoxin

C.2Fe-2S

D.plastocyanin

Question 5 of 10 0.0/ 1.0 Points

Protons from electron transport will amass in the

A.stroma

B.intermembrane space

C.matrix

D.thylakoid lumen

Question 6 of 10 1.0/ 1.0 Points

Organic molecules are made in the _______________ .

A.light dependent reactions

B.Calvin cycle

C.Krebs cycle

D.glycolysis

Question 7 of 10 1.0/ 1.0 Points

What statement shows the relationship among chloroplasts and mitochondria?

A.both release carbon dioxide

B.both generate ATP by proton gradient

C.both reduce NADP+

D.both use oxygen as the final electron acceptor

Question 8 of 10 1.0/ 1.0 Points

What properties are expressed by wavelengths? Select all that apply.

A. Red absorbs little energy

B. Visible light’s wavelengths are between 400-740nm

C. Green is useful in absorbing light during photosynthesis

D. Visible light’s wavelengths are between 400-740nm

E. Chlorophyll b absorbs a lot of energy from 460nm wavelengths

F. Chlorophyll a reflects red light well

Question 9 of 10 1.0/ 1.0 Points

If rubisco does not function properly, what process would be affected?

A.ability to fix carbon

B.ability to split water

C.ability to reduce NADP+

D.ability to absorb photons

Question 10 of 10 1.0/ 1.0 Points

____________ membranes can be found in a chloroplasts.

A.1

B.2

C.3

D.4

Chapter 9- wk 6

Return to Assessment List

Part 1 of 1 – 7.0/ 10.0 Points

Question 1 of 10 0.0/ 1.0 Points

What describes transcription factors?

A.control of gene expression

B.regulation of DNA duplication

C.ATP into cAMP

D.synthesis of glycogen

Question 2 of 10 1.0/ 1.0 Points

Cell surface receptors have three domains with different roles. Match each role to the domain that is responsible.

A. Hydrophobic domain

B. Extracellular domain

C. Cytosolic domain

________________________________________

1. Binds the signaling molecule ________

2. Sends conformational change through the plasma membrane ________

3. Interacts with downstream signaling cascade ________

Question 3 of 10 0.0/ 1.0 Points

If calcium levels are low, cAMP activity increases which leads to synthesis and release of parathyroid hormone. cAMP acts as a(n)

A.enzyme

B.phosphorylating agent

C.ligand

D.second messenger

Question 4 of 10 1.0/ 1.0 Points

Diacylglycerol and inositol triphosphate are released from phosphatidylinositol biphosphate by ________ .

A.adenylyl cyclase

B.phospholipase C

C.protein kinase C

D.G-protein

E.A-kinase

Question 5 of 10 1.0/ 1.0 Points

________ is the substrate for adenylyl cylcase.

A.GDP

B.cAMP

C.ADP

D.GTP

E.ATP

Question 6 of 10 0.0/ 1.0 Points

Protein phosphorylating enzymes help regulated gene expression by

A.moving mRNA into the cytoplasm

B.translation

C.DNA synthesis

D.protein activation

Question 7 of 10 1.0/ 1.0 Points

A common theme in many pathways is a cascade of similar enzymes acting on each other in sequence. For instance, MAP kinase kinase kinase adds a phosphate to MAP kinase kinase, which adds phosphate to MAP kinase, which adds phosphate to another substrate.

What is the benefit of using a cascade of enzymes?

A.Extra genes provide backup in case the original became mutated.

B.A cascade amplifies output from the original signal.

C.There is no benefit – “selfish genes” are often maintained in evolution for reasons unrelated to the function of their encoded proteins.

D.A cascade is used for timing since it delays the response.

Question 8 of 10 1.0/ 1.0 Points

Vibrio fischeri are bioluminescent when the population reaches a certain size. This is an example of

A.population density

B.quorum sensing

C.exponential growth

D.principle of growth

E.binary fission

Question 9 of 10 1.0/ 1.0 Points

Since plants have rigid cell walls formed from cellulose, transfer of information and materials between cells is prohibited.

True

False

Question 10 of 10 1.0/ 1.0 Points

Teeth can have a biofilm formed on the surface. Cell signaling will

A.increase cell quantity

B.cause increase saliva production

C.cause apoptosis

D.cause uncontrolled cell division

!

Chapter 10- wk 7

Return to Assessment List

Part 1 of 1 – 9.0/ 10.0 Points

Question 1 of 10 1.0/ 1.0 Points

Which molecule initiates the halt of the cycle when damaged DNA is detected in G1?

A.Rb

B.p53

C.Cdk/cyclin complex

D.p21

E.E2F

Question 2 of 10 0.5/ 1.0 Points

In which type of human cell(s) would 46 chromosomes be located? Select all that apply.

A. diploid

B. egg

C. somatic

D. gamete

E. sperm

F. haploid

Question 3 of 10 1.0/ 1.0 Points

If there are 8 centromeres in metaphase, how many centromeres will be present in anaphase?

A.4

B.8

C.16

D.32

Question 4 of 10 1.0/ 1.0 Points

A large cell will be initiated to divide because

A.a decrease in surface-to-volume ratio

B.an increase in surface-to-volume ratio

C.crowding from smaller cells

D.large cells do not experience quiescent stage

E.large cells use more nutrients than small cells

Question 5 of 10 0.5/ 1.0 Points

Damaged DNA can potentially be repaired during which checkpoint. Select all that apply.

A. G1

B. S

C. G2

D. G0

E. M

Question 6 of 10 1.0/ 1.0 Points

Place the order of events in chromosome packaging from beginning to end.

A.DNA double helix, nucleosome, sister chromatids, chromatin

B.Chromatin, nucleosomes, DNA double helix, sister chromatids

C.DNA double helix, chromatin, nucleosomes, sister chromatids

D.sister chromatids, DNA double helix, chromatin, nucleosome

Question 7 of 10 1.0/ 1.0 Points

In nature, there is an exception to every rule. Of the species below, which one has a very unusual genome that violates the “rule”?

A.Borrelia burgdorferi, the bacterium responsible for Lyme disease, has a linear genome and up to 21 plasmids.

B.E. coli, a common bacterium in the human intestine, has DNA nucleotides A, T, C, and G, with only one OH group on the sugar moiety.

C.Humans have a genome formed from 23 pairs of linear chromosomes, each of which is so long that it must be wrapped up and condensed into a special structure to fit in the nucleus.

D.Arabidopsis pollen is haploid, carrying only one copy each of five linear chromosomes.

Question 8 of 10 1.0/ 1.0 Points

When the p53 gene is damaged, which event may happen?

A.Cells can divide uncontrollobly

B.Cells will fix the DNA pass the G1 checkpoint

C.Cells will pass the G2 checkpoint

D.Cells will always undergo apoptosis

Question 9 of 10 1.0/ 1.0 Points

A cell’s entire amount of hereditary information is the

A.nucleoid

B.nucleus

C.genome

D.DNA

Question 10 of 10 1.0/ 1.0 Points

If a researcher looks at a cell and notices a straight line of sister chromatids, which phase are they viewing?

A.interphase

B.prophase

C.prometaphase

D.metaphase

E.anaphase

F.telophase

Chapter 11- wk 7

Return to Assessment List

Part 1 of 1 – 5.75/ 10.0 Points

Question 1 of 10 1.0/ 1.0 Points

What is an advantage of asexual reproduction? Select all that apply.

A. it occurs quickly

B. populates areas rapidly

C. all organizms are clones

D. high genetic diversity

E. only need one parent

Question 2 of 10 0.0/ 1.0 Points

An organism has 36 chromosomes. At the end of meiosis I, each gamete contains

A.26 chromosomes, 36 chromatids

B.36 chromosomes, 72 chromtids

C.18 chromosomes, 36 chromatids

D.18 chromosomes, 18 chromatids

Question 3 of 10 1.0/ 1.0 Points

Which is important in stabilization of homolog pairing and formation of crossover in meiotic prophase?

A.A

B.B

C.C

D.D

E.E

Question 4 of 10 1.0/ 1.0 Points

Meiosis and sexual reproduction increase diversity because

A.they are archaic processes

B.it allows for populations to adapt to environmental changes

C.they only need one parent

D.they will almost always have different offspring arise

E.they produce offspring extremely quickly

Question 5 of 10 0.75/ 1.0 Points

Which event is similar between prophase I and prophase? Select all that apply.

A. The nuclear membrane begins to disintegrate

B. Spindle fibers appear

C. Each chromosome is composed of two chromatids

D. Chromosomes condense

E. Each chromosome has potentially experienced crossover

F. Tetrads are present

Question 6 of 10 1.0/ 1.0 Points

A large family has a history of multiple aneuploid diseases such as Down Syndrome, trisomy-18 and Klinefelter Syndrome (XXY). The propensity to defects seems to be inherited, but the gene responsible is unknown.

What types of candidate genes would be most likely to lead to aneuploidy if they were mutated?

A.Genes that are part of the G1 checkpoint of mitosis.

B.Genes that encode proteins involved in chiasma formation.

C.Histone genes.

D.Genes that control DNA synthesis.

Question 7 of 10 0.0/ 1.0 Points

A nuclear envelope does not usually form around each set of chromosomes in the haploid daughter cells in _________.

A.interphase

B.prophase I

C.metaphase I

D.anaphase I

E.telophase I

F.prophase II

G.metaphase II

H.anaphase II

I.telophase II

J.cytokinesis

Question 8 of 10 0.0/ 1.0 Points

Which structure is separated by microtubules resulting in sister chromatids?

A.A

B.B

C.C

D.D

Question 9 of 10 1.0/ 1.0 Points

Which describes the relationship between gametes and spores?

A.gametes can fuse to become a zygote, but spores can develop into organisms without forming a zygote

B.gametes, not spores, can only contribute to genetic diversity in populations

C.gametes are always haploid and spores are always diploid

D.gametes come directly from sporophytes to develop into gametophytes

Question 10 of 10 0.0/ 1.0 Points

How does metaphase in meiosis I and meiosis II differ?

A.Sister chromatids are on the metaphase plate in meiosis I and tetrads are on the metaphase plate in meiosis II.

B.Homologous chromosomes line up in meiosis I and duplicated chromosomes line up in meiosis II.

C.All chromatids are the exact same in meiosis I and differ in meiosis II due to independent assortment

D.The ploidy level remains the same in meiosis I but will be reduced in meiosis II.

 
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Chromosomes and Inheritance

Name:       Sec:      

Chapter 5: Chromosomes and Inheritance

Module 5.6. Gametes have half as many chromosomes as body cells.

1.       is the process that results from the union of gametes from two different parents.

2. A skin cell is to a somate as a(n) ________ is to a gamete.

A) |_| embryo

B) |_| zygote

C) |_| brain cell

D) |_| egg

3. Determine whether each of the following cells is haploid or diploid:

A) An egg      

B) A cell from your liver      

C) A zygote      

D) A sperm      

E) A cell from your heart      

4. A normal human egg or sperm has 23 chromosomes, which is exactly one half what a somate has. Briefly explain what would happen every generation if gametes were actually diploid.

     

5. _______contain the same genes at the same locations.

A) |_| Sex chromosomes

B) |_| Autosomes

C) |_| Gametes

D) |_| Homologous chromosomes

6. Are the two chromosomes shown here homologous? Briefly explain why or why not.

UN_05_008

     

7. Can a karyotype be used to determine the gender of an individual? Briefly explain your answer.

     

Module 5.7. Meiosis produces gametes.

8.       is the type of cell division that produces gametes.

9. A similarity that meiosis shares with mitosis is which of the following:

A) |_| They both undergo chromosome duplication.

B) |_| They both have two rounds of cell division.

C) |_| They both occur in somatic cells.

D) |_| They both have only one round of cell division.

10. Fill in the following table (yes or no) contrasting mitosis and meiosis:

Mitosis

Meiosis

Chromosomes duplicate prior to cell division

     

     

Chromosomes condense prior to division

     

     

How do chromosomes line up prior to cell division

     

     

11. Is the following cell in undergoing mitosis or meiosis. Assume the starting cell was diploid and had two pairs of chromosomes. Briefly explain your answer.

UN_05_009

     

12. True for False; If false make a true statement: At the end of meiosis I, the two cells are both diploid.

     

13. At the end of meiosis II, there are ____ cells and they are all ____.

A) |_| four; diploid

B) |_| two; haploid

C) |_| four; haploid

D) |_| two; diploid

Module 5.8. Mitosis and meiosis have important similarities and differences.

14. Mitosis is to a somate as meisosis is to a(n)      .

15. Give an example of a cell in your body that undergoes mitosis. How many chromosomes does that cell have?

     

16. Mitosis creates ____, while meiosis creates ____:

A) |_| haploid gametes; diploid gametes

B) |_| diploid somates; diploid gametes

C) |_| haploid somates; haploid gametes

D) |_| diploid somates; haploid gametes

17. A cell biologist observes a cell under a microscope and determines that the cell contains nine chromosomes. Is this cell diploid or haploid? Briefly explain.

     

Module 5.9. Several processes produce genetic variation among sexually reproducing organisms.

18. The process of a sperm and egg uniting is called:

A) |_| crossing over

B) |_| independent assortment

C) |_| fertilization

D) |_| mitosis

19. Sexual reproduction produces a tremendous amount of diversity in organisms. List three ways in which this diversity is accomplished.

1.      

2.      

3.      

20. Each homologous pair of chromosomes can line up in one of two orientations. This kind of alignment is known as      .

21. A biologist is studying cells from a new organism recently discovered in a rain forest. He determines that the somates contain a total of eight chromosomes. How many possible combinations of chromosomes could this organism produce as a result of independent assortment? Assume the organism reproduces sexually.

     

22. Explain why the term crossing over is accurate for the process it names.

     

23. Crossing over produces:

A) |_| hybrid chromosomes

B) |_| independent assortment

C) |_| random fertilization

D) |_| a zygote

UN_05_01124. Has the homologous pair of chromosomes in the following figure undergone crossing over? Explain your answer.

     

Module 5.10. Mistakes during meiosis can produce gametes with abnormal numbers of chromosomes.

25. The failure of chromosomes to separate properly is known as      

26. True or False; If false, make a true statement: Nondisjunction always results in a zygote with the incorrect number of chromosomes.

     

27. A human zygote is created from a sperm that contained an extra chromosome 21. How many total chromosomes did the sperm contain? How many chromosomes does the zygote have?

     

28. Does the individual from the karyotype shown here have a normal number of chromosomes? If not, what syndrome does he or she have?

UN_05_012

     

29. Complete the following table regarding sex chromosome abnormalities:

Sex chromosomes

Syndrome

Sex

     

Klinefelter syndrome

     

XYY

     

     

     

     

Female

XO

     

     

30. An individual is determined to have Jacob’s syndrome. Is it possible to determine which parent’s gamete had the incorrect number of chromosomes? If so, which one was it? Briefly explain your answer either way.

     

 
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300 Words Essay- Scientific Method (D1)

Thinking as a Scientist
After considering the scientific method explained in the textbook, write an essay about how it compares to the way nonscientists approach problems. Identify some problems that are solvable scientifically and some that are not. Using one or two small problems, describe the process you would go through in solving that problem using the scientific method. Discuss the significance of the scientific approach to the development and advancement of human knowledge. Your essay should be about 300 words.

The Scientific Method
Biology consists of a great deal of knowledge. Much of that knowledge takes the form of facts that we refer to as theories. Or perhaps this is better understood by saying that biologists treat theories as though they were facts. But, they are special kind of fact. They are not a fact the way your social security number is a fact. A theory is a fact that has been derived using the scientific method.

The scientific method always starts with an observation. And notice carefully that we use the singular word, observation, and not the plural ‘observations’, even if a thousand events were observed. The observation leads to a question. Questions come in many shapes and forms, but the scientific method needs to pose only very specific questions. This is because the question must be able to be worded as a hypothesis. What is a hypothesis? A hypothesis is a specific statement in which a cause and effect scenario is central. For an example, follow along with the scenarios presented in the assigned textbook readings. You will see that a hypothesis can never be an open ended question. It must be specific. For example, this is a hypothesis: If I put a cover over a flame, it will go out. This is not a hypothesis: Why does the flame go out when I put a cover over it? After you have created a hypothesis, you design experiments to see if you can support your hypothesis. Keep in mind that in the biological sciences, while you can support a hypothesis, you can never prove one. This is one of the most misunderstood concepts in science. You will never account for every possible condition for a given hypothesis; therefore, you can never prove it beyond any shadow of doubt.

 
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