Evolution of Genes and Culture

LESSON

 

 

evolution of Genes and Culture

 

 

 

 

LESSON

 

STUDENT MATERIALS

 

The Making of the Fittest:

 

Got Lactase? The Co

evolution of Genes and Culture

 

 

 

 

LESSON

 

STUDENT MATERIALS

 

The Making of the Fittest:

 

Got Lactase? The Co

evolution of Genes and Culture

 

 

 

The Making of the Fittest: Natural

GOT LACTASE? BLOOD GLUCOSE DATA ANALYSIS

INTRODUCTION

“Mother’s milk” is packed with the proteins, fats, and carbohydrates that support the growth, development, and survival of baby mammals. The sugar lactose is the main carbohydrate in milk. Lactose can be cleaved into two simpler sugars, glucose and galactose, by lactase, an enzyme produced in the small intestine. The two smaller sugars are readily absorbed though the intestinal wall into the bloodstream for delivery to the cells of the body, where they are used for energy.

 

 

After infant mammals are weaned from their mother’s milk, lactase production shuts down, presumably because it is no longer needed. This condition is called lactase nonpersistence—meaning that production of the lactase enzyme does not persist into adulthood. The general condition for mammals is not to consume milk after weaning and to be lactase nonpersistent. Some populations of humans are unusual in that adults continue to consume milk from other mammals, such as cows.

If a person who is lactase nonpersistent drinks milk, undigested lactose passes from the small intestine to the large intestine, where it is fermented by bacteria. Fermentation produces various gases in the large intestine, which can cause abdominal pain, bloating, flatulence, and diarrhea—all symptoms of lactose intolerance. Worldwide, most adults are lactose intolerant, although some people may not know it because their symptoms are mild. Only a minority of human adults (about 35% of the global human population) continues to produce lactase into adulthood and can drink milk without any problems. These individuals are said to be lactase persistent or lactose tolerant.

There are several ways to test whether someone is lactase persistent. In the short film, Got Lactase? The Co-evolution of Genes and Culture, the narrator, Dr. Spencer Wells, takes a blood glucose test to deduce his lactase status. In this activity you will examine the results of blood glucose tests conducted on six different adults to determine who is lactase persistent (lactose tolerant) or lactase nonpersistent (lactose intolerant).

MATERIALS

· Ruler

· Colored pencils

 

 

 

 

Got Lactase? Blood Glucose Data Analysis

Updated November 2014

 

 

 

 

 

www.BioInteractive.org

 

 

 

 

 

 

 

 

 

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PROCEDURE

1. Examine the data in the table below. It shows the blood glucose levels of six individuals tested in Dr. Sarah Tishkoff’s laboratory. After baseline (i.e., time 0 minutes) blood glucose levels were measured and recorded, each person drank a liter of milk. Blood glucose levels were again measured at 15, 30, 45, and 60 minutes after drinking the milk. Glucose levels were measured using glucose strips and a glucose reader similar to the one Dr. Wells used in the film.

 

  Blood Glucose (mg/dL)      
Individual 0 minutes 15 minutes 30 minutes 45 minutes 60 minutes
Spencer Wells 117 128 146 160 152
Peter 97 111 135 154 143
Rachel 96 99 105 101 98
Katherine 95 97 99 101 102
Sarah 108 116 129 141 139
Michael 94 109 128 143 140
Arthur 97 96 94 83 88

 

2. Plot the results from the six individuals in the graph below. The graph already includes Dr. Wells’ blood glucose test results. Make sure to include a legend for your graph.

 

Lactase Persistence Blood Glucose Test Results

 

80

90

100

110

120

130

140

150

160

0

10

20

30

40

50

60

Blood Glucose (mg/dL)

 

Time (minutes)

Spencer Wells

 

 

3. After graphing the data, answer the questions below.

QUESTIONS

1. Why is measuring blood glucose levels an indicator of someone’s lactase activity?

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2. Divide these individuals into two groups (A and B), based on their blood glucose test results. Write the names of the individuals in each group, including Dr. Spencer Wells.

Group A:

 

Group B:

 

3. Explain your rationale for dividing the individuals into these two groups using data to support your answer.

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4. Based on these data, do you predict that individuals in Group A are lactase persistent or nonpersistent? Describe the evidence that supports this claim.

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5. Based on these data, do you predict that individuals in Group B are lactase persistent or nonpersistent? Describe the evidence that supports this claim.

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6. If you performed the same blood glucose test on a group of people who are from the Maasai population in Kenya, predict whether their results would be more like those of Group A or Group B. Explain your prediction.

(Hint: Remember from the film that the Maasai people are pastoralists.)

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7. A person taking a blood glucose test is usually told to fast prior to the test. Why do you think that might be necessary?

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Epidemiology

Question 1 

Which of the following is not usually an aim of epidemiology?

 

To describe
the health status of the population

 

To fund   new public health programs

 

To explain
the etiology of disease

 

To predict
the occurrence of disease

 

To control
the distribution of disease

Question 2 

Which of the following activities characterizes an epidemiologic approach (as opposed to a clinical approach)?

 

Description   of a single individual’s symptoms

 

Surveillance   of a population

 

Treatment   of a patient with diagnosed illness

 

A and   C

Question 3 

In the Yearly Mortality Bill for 1632, consumption referred to:

 

dysentery

 

tuberculosis

 

smallpox

 

edema

Question 4 

Which of the following activities characterizes a clinical approach (as opposed to an epidemiologic approach)?

 

Description   of specific signs and symptoms in a patient

 

Description   of seasonal trends in disease occurrence

 

Examination   of disease occurrence among population groups

 

Demonstration   of geographic variations in disease frequency

Question 5 

Cyclic variations in the occurrence of pneumonia and influenza mortality may reflect:

 

seasonal   variations in cases of influenza.

 

the   fact that influenza is a disappearing disorder.

 

long-term   changes in mortality trends.

 

both   A and B

Question 6 

The Epidemic Intelligence Service (EIS) is responsible for (give the best answer):

 

tracking   down unusual disease outbreaks in the United States and foreign countries.

 

collecting   routine epidemiologic data for local health departments.

 

printing   epidemiologic reports for members of the community.

 

reporting   suspicious bioterrorism agents to governmental agencies

Question 7 

John Snow, author of Snow on Cholera:

 

was   the father of modern biostatistics.

 

established   postulates for transmission of infectious disease.

 

was   an early epidemiologist who used natural experiments.

 

argued   that the environment was associated with diseases such as malaria.

Question 8 

Indicate the level of prevention that is represented by pasteurization of milk

 

Primary   Prevention Active

 

Primary   Prevention Passive

 

Secondary   Prevention

 

Tertiary   Prevention

Question 9 

Using epidemiology for operational research involves:

 

study   of community health services

 

study   of risks to the individual

 

study   of disease syndromes

 

study   of disease symptoms

Question 10 

Increases in lung cancer mortality, especially among women, illustrate which of the following trends in disease occurrence?

 

A   residual disorder

 

A new   epidemic disorder

 

A   persistent disorder

 

A   disappearing disorder

Question 11 

Indicate the level of prevention that is represented by screening for breast cancer

 

Primary   Prevention Active

 

Primary   Prevention Passive

 

Secondary   Prevention

 

Tertiary   Prevention

Question 12 

In 1900, the death rate per 100,000 members of the population for influenza and pneumonia (I & P) was 202.2; it was 22.4 in 2003. How much did the death rate due to I & P decline?

 

100%

 

1000%

 

90%

 

9000%
Question 13 

Indicate the level of prevention that is represented by nutritional counseling for pregnant women

 

Primary   Prevention Active

 

Primary   Prevention Passive

 

Secondary   Prevention

 

Tertiary   Prevention

Question 14 

Indicate the level of prevention that is represented by immunization against rubella

 

Primary   Prevention Active

 

Primary   Prevention Passive

 

Secondary   Prevention

 

Tertiary   Prevention

Question 15 

The risk of acquiring a given disease during a time period is best determined by:

 

the   mortality rate from that disease in the 0-4 age group.

 

a   spot map that records all cases of the disease in the past year.

 

the   period prevalence for that disease during the past year.

 

the   incidence rate (cumulative incidence) for that disease in a given period of   time.

Question 16 

Beach City has a rising population of 500,000 robust, fertile males and 450,000 robust, fertile females. If there were 4,000 live births, 3 fetal deaths, and 40 maternal deaths, what is the crude birth rate?

 

4,000/500,000   × 1,000

 

4,000/450,000   × 1,000

 

4,000/950,000   × 1,000

 

4,003/950,000   × 1,000

 

3,997/950,000   × 1,000

Question 17 

An epidemiologic survey of roller-skating injuries in Metroville, a city with a population of 100,000 (during the midpoint of the year), produced the following data for a particular year:
 

Number of skaters in   Metroville during any given month

12,000

 

Roller-skating   injuries in Metroville

600

 

Total number of   residents injured from roller-skating

1,800

 

Total number of   deaths from roller-skating

90

 

Total number of   deaths from all causes

900

 

The crude death rate for all causes was:

 

90/600   × 100,000

 

900/100,000   × 100,000

 

90/1,800   × 100,000

 

90/900   × 100,000

Question 18 

Determining workload and planning the scope of facilities and manpower needs, particularly for chronic disease. Is this a use for incidence or prevalence data?

 

This   is a use primarily for incidence data.

 

This   is a use primarily for prevalence data.

 

This   application could apply equally for both incidence and prevalence data.

 

This   is a use for neither incidence data nor prevalence data.

Question 19 

An epidemiologic survey of roller-skating injuries in Metroville, a city with a population of 100,000 (during the midpoint of the year), produced the following data for a particular year:
 

Number of skaters in   Metroville during any given month

12,000

 

Roller-skating   injuries in Metroville

600

 

Total number of   residents injured from roller-skating

1,800

 

Total number of   deaths from roller-skating

90

 

Total number of   deaths from all causes

900

 

The proportional mortality ratio (%) due to roller-skating was:

 

90/600   × 100

 

90/100,000   × 100

 

90/1,800   × 100

 

90/900   × 100

Question 20 

The fundamental tool for etiologic studies of both acute and chronic diseases. Is this a use for incidence or prevalence data?

 

This   is a use primarily for incidence data.

 

This   is a use primarily for prevalence data.

 

This   application could apply equally for both incidence and prevalence data.

 

This   is a use for neither incidence data nor prevalence data

Question 21 

The incidence of a disease is five times greater in men than in women, but the prevalence shows no sex difference. The most likely explanation is that:

 

the   mortality rate is greater in women.

 

the   case fatality rate is greater in women.

 

the   duration of the disease is greater in women.

 

women   receive less adequate medical care for the disease

Question 22 

To provide a direct estimate of the risk of developing a disease. Is this a use for incidence or prevalence data?

 

This   is a use primarily for incidence data.

 

This   is a use primarily for prevalence data.

 

This   application could apply equally for both incidence and prevalence data.

 

This   is a use for neither incidence data nor prevalence data.

Question 23 

A null hypothesis is most similar to which of the following?

 

Positive   declaration

 

Negative   declaration

 

Implicit   question

 

Explicit   question

Question 24 

Age-specific and age-adjusted mortality rates by sex in the United States generally show the following sex differences:

 

Rates   for males are higher than rates for females from birth to age 85 and older.

 

Rates   for females are higher than rates for males from birth to age 85 and older.

 

Rates   for males are higher than rates for females from age 6 to age 85 and older.

 

Rates   for males are equal to rates for females during the first 5 years of life.

Question 25 

The use of GIS may be thought of as following the heritage of:

 

Hippocrates

 

Graunt

 

Snow

 

Koch

 

Semmelweis

Question 26 

Which of the following statements most accurately expresses the breeder hypothesis for schizophrenia?

 

The   conditions of life in lower-class society favor its development.

 

The   conditions of life in upper-class society favor its development.

 

The   illness leads to the clustering of psychosis in the impoverished areas of a   city.

 

The   illness is associated with increases in creative talents, which contribute to   wealth-enhancing achievements.

Question 27 

Lung cancer mortality among women is increasing faster than among men. What factor(s) would most likely account for this increased cancer rate?

 

Younger   women are smoking more.

 

Older   women are smoking more.

 

Women   are smoking less.

 

Men   are smoking more

Question 28 

According to classic studies, age-standardized morbidity rates in the United States for acute conditions, chronic conditions, and disability due to acute conditions show the following sex differences:

 

Rates   for males are higher than rates for females.

 

Rates   for females are higher than rates for males.

 

Rates   for males are equal to the rates for females.

 

Females   have higher rates of hearing impairment than males.

Question 29 

Studies of nativity and migration have reported that:

 

admission   rates of foreign-born persons to mental hospitals were lower than for   native-born persons

 

diseases   found in less developed regions are no longer a problem in the United States

 

immunization   programs in developing countries have been highly successful

 

some   migrants have inadequate immunization status with respect to   vaccine-preventable diseases

Question 30 

Which of the following statements most accurately expresses the downward-drift hypothesis for schizophrenia?

 

The   conditions of life in lower-class society favor its development.

 

The   conditions of life in upper-class society favor its development.

 

The   illness leads to the clustering of psychosis in the impoverished areas of a   city.

 

The   illness is associated with increases in creative talents, which contribute to   wealth-enhancing achievements.

 
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Popular Culture’s Perceptions of Sexuality and Elderly People

Assignment 2: Popular Culture’s Perceptions of Sexuality and Elderly People

 

Complete a web search to find a cartoon or advertisement in the popular media that conveys an image or message related to sexuality and older people. Examine the medium’s portrayal of sexuality in older adults by answering the following questions. Also, attach or provide the url of your cartoon or advertisement with your assignment submission.

Using a minimum of 1000 words, answer the following questions.  Be sure to use outside references (formatted in APA style) to support your conclusions.  Your job is to convince me that you have a clear understanding of the issues surrounding sexuality and the elderly.

  1. What is the message of the popular media cartoon, or advertisement?
  2. What examples of physiological, psychological, or social aspects of sexual development are conveyed? Explain.

 

  Possible points Student points and instructor feedback
The writer establishes a clear message from the chosen medium. All supporting ideas are strongly related to the topic. the 1000 word minimum is met. 30  
Examples of physiological, psychological, or social aspects of sexual development are clearly conveyed and evaluated. 30  
Responses are thoughtful and engaging. The writer may choose to use his/her unique experiences or view of the world as a basis for writing or to connect ideas in interesting ways. 30  
References are included in summaries and follow APA 6th ed. formatting style. 10  
Total 100  

 

 
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Virtual Lab 5: Ecosystem simulator

Virtual Lab 5: Ecosystem simulator

Read the Overview and launch this ecolosystem simulator . Familiarize yourself with the simulator interface. Notice that you can control which species are present in your environment initially and what the diets of each species are. The types of species possible in the program are Plants (A,B,C), Herbivores (A,B,C), Omnivores (A,B) and one top Predator. You can control the diet of each by indicating what they feed on. By setting up different starting configurations you can investigate the evolution of this simulated ecological system.

A. In a couple of sentences describe what happens when you start with only two (A&B) and then all three plant species present.

When only A & B plant species are there and we run the stimulator, the population of Plant a increases and becomes maximum and that of plant B decreases to 0. As the time passes by, species of A decreases and that of B increases such that in long run we have equal distribution of Species A & B.

When we run the simulator with all the three plant species, The consequence of Plant A & B is same but there is no plant of type C.

In this case there are only producers. They harness the sun energy and grow. The favourable ones boom and the others are overshadowed in the process.

B. Describe how many herbivores and omnivores you added (and what they eat) in order to create an ecosystem in which all three plant species can coexist. (if you cannot accomplish the survival of Plant C describe your best configuration. Describe your ecologies by identifying the species present and their diet, for instance:

Omnivore A eats Herbivore A, Herbivore A eats plant A and plant B, Herbivore B eats plant A, All plants present.

All the three varieties of plant A, B & C co-exists when we add Herbivore A, B, & C

Herbivore A eats Plant A & C, Herbivore B eats Plant A & B and Herbivore C Eats Plant B & C.

Omnivore A eats Herbivore A & B and Omnivore B eats Herbivore B & C

Top Predator eats both Omnivore A & B. In this ecosystem all the varieties have a co-existence.

C. If you can accomplish part B, see if you can get all of the species to coexist. (limit your time on this entire experiment to 90 minutes)

D. If we assume that this simulation is a reasonable oversimplification of a typical ecosystems food web what does it tell us about biodiversity and ecology- are they robust or fragile? In general is an ecosystem’s biodiversity preserved as it responds to change?

Virtual Lab 6: Evolution: Sex and the Single Guppy

This simulation follows a set of real life experiments in evolution and natural selection. Familiarize yourself with the interface, guppies, guppy predators, and the experiment. Use an “even mix” of the different guppy color types to start. Run three experiments one with each of the combination of predators. Each experiment should run for five or more generations. Type your solutions in bold face text.

•   State the percentage that each color type makes up in your guppy population both before and after you have let five generations pass. With each experiment state a conclusion that is consistent with your observation.

1. Rivulus only

131 guppies

2. Rivulus and Acara

3. Rivulus, Acara and Cichlids.

•   What two selection pressures are operative?

Virtual Lab 7: Anatomy and Dissections

A. Dissections

1. Earthworm

A. Identify items 1 & 2 on the external dorsal (back side) surface of the worm.

B. Identify items 3, 4, & 5 on the external ventral (belly side) of surface of the worm.

C. Identify item 2 in the image of the worm’s internal morphology w/o the digestive tract.

D. Describe sexual reproduction in worms.

2. Fetal Pig

A. Use the Anatomical References guide. To what region of the body does dorsal, ventral, anterior, and posterior refer to?

B. Investigate the Nervous system. The pig is similar to the human in many ways.

Name four large regions (lobes) of the brain and indicate where they are located and what functions they have in humans.

B. Comparative Hominid Anatomy

•   Compare the the skull casts of a chimp, AustralopithicusHomo erectusneanderthal, and modern Homo sapiens. Be sure to use the lateral view.

•   Describe features that are common and different between the cranial structure of these creatures. What patterns do you see? •   Describe the basic timeline and sequence of evolution for the creatures listed above. Be explicit.

Virtual Lab 8: Human Impact

A. Water footprints

•   Describe the water crisis. How is it impacting women and children globally? What is happening with the Ogalala (be specific)?

Water crisis refers to lack of access to safe water sources. Inadequate drinking water supply is among the world’s major causes of preventable morbidity and mortality.

Water related health burdens are borne by women and children who may forego schooling and childhood in order to transport water from distant sources. Women and children are also often responsible for the gathering of fuel wood both for cooking and for boiling the polluted water.

The High Plains stretch northward from West Texas to Wyoming and South Dakota, and in natural conditions form a dry grassland. There is less than 16 inches of rain a year near the Rockies and in West Texas, but that increases eastward to 28 inches in central Kansas. The rainfall varies a great deal from year to year, however. The steady gradient of increasing rain to the eastward, but varying yearly rainfall, means that the optimal western limit for growing crops such as corn, rather than grazing cattle, shifts each year. This problem is made worse because there is hardly any water surplus: evaporation levels are very close to precipitation levels. Apart from the constraints on farming, this fact means that there is little recharge of ground water from precipitation: ground water percolates only very slowly eastward in underground aquifers from the areas where Rocky Mountain snowmelt recharges them.

The United States Geological Survey (USGS) began intensive research on the Ogallala in 1978. It found that the Ogallala had discharged perhaps 3 maf/yr into springs and rivers before development: this, then, would be a sustainable yield from the aquifer as it used to be, compared with the 1980 pumping rate of 18 maf/yr.

•   Describe what the water footprint is and how it is estimated.

The water footprint of an individual, community or business is defined as the total volume of freshwater used to produce the goods and services consumed by the individual or community or produced by the business. Water use is measured in water volume consumed (evaporated) and/or polluted per unit of time.

A water footprint can be calculated for any well-defined group of consumers (e.g., an individual, family, village, city, province, state or nation) or producers (e.g., a public organization, private enterprise or economic sector). The water footprint is a geographically explicit indicator, not only showing volumes of water use and pollution, but also the locations. However, the water footprint does not provide information on how the embedded water negatively or positively affects local water resources, ecosystems and livelihoods.

•   Report the two or more estimates of your water footprint (and the calculator(s) that you used).

image1.png

http://www.gracelinks.org/1408/water-footprint-calculator

•   Describe three ways that you (or your society) could reduce your water footprint.

We can use public transport, or pooled vehicles for going to office , we can decrease the use of gasoline

We should not waste potable water. We can store rain water and use for watering our plants.

B. Carbon footprints

•   Describe what has happened to atmospheric CO2 over the last 100,000 years and how this is thought to be impacting the climate.

Over the last 100,000 CO2 content has been increasing due to excessive use of fuel, human population, large scale deforestation

In the distant past (prior to about 10,000 years ago), CO2 levels tended to track the glacial cycles. During warm ‘interglacial’ periods, CO2 levels have been higher. During cool ‘glacial’ periods, CO2 levels have been lower.  This is because the heating or cooling of Earth’s surface can cause changes in greenhouse gas concentrations.

•   Describe what the carbon footprint is and how it is estimated.

Carbon footprint is a shorthand to describe the best estimate that we can get of the full climate change impact of something. That something could be anything – an activity, an item, a lifestyle, a company, a country or even the whole world.

An individual’s, nation’s, or organisation’s carbon footprint can be measured by undertaking a GHG emissions assessment or other calculative activities denoted as  carbon accounting 

•   Report two or more estimates of your carbon footprint (and the calculator(s) that you used).

image2.png

http://www.carbonfootprintofnations.com/content/calculator_of_carbon_footprint_for_nations/

•   Describe two ways that you (or your society) could reduce your carbon footprint.

One of the most popular ways utilizes trees in a process called Carbon Sequestration.  Trees naturally absorb CO2 and release oxygen back into the environment.  You only need to know how many trees it takes to offset your Carbon Footprint.  Every tree is different and absorb these emissions at different rates depending on type and age. 

The most common way to reduce the carbon footprint of humans is to  Reduce, Reuse, Recycle . In manufacturing this can be done by recycling the packing materials, by selling the obsolete inventory of one industry to the industry who is looking to buy unused items at lesser price to become competetive. Nothing should be disposed off into the soil, all the ferrous materials which are prone to degrade or oxidise with time should be sold as early as possible at reduced price.

•   Describe two ways that you would advocate we adapt society-wide in order to reduce our national carbon footprint. Be explcit.

The national carbon footprints can be reduced by reducing our energy consumption. We should use less of Air conditioning and warming systems.

We should use less fuel and try to save water consumption. We should go in for public transport system and use cycles for transportation to nearby areas.

We should recycle material like newspaper use recycled paper. We should recycle rain water and use it for gardens.

 
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