Week 7 Assignment : Pick your Pathogen

Submit Assignment

· Due Saturday by 12pm EST

 

· Points 50

 

· Submitting a file upload

Required Resources Read/review the following resources for this activity:

· Textbook: Chapter 21, 22, 23

· Lesson

· Minimum of 2 scholarly sources

Instructions

Objective: Select a publication or a newspaper article on a pathogen, apply knowledge learned in BIOS242, and write a paper.

The goal for this project is:

· to make connections between concepts learned in the course and what is observed in a health care setting

· to understand real-life applications of Microbiology

Project Parameters: For this assignment, you will identify a pathogen in a newspaper article or publication of your choice, apply principles learned in BIOS 242, and research the pathogen for its connection to nursing/health care. You must get approval for your chosen article and pathogen. You will then write a paper on their chosen pathogen/topic.

The pathogen can be a bacteria, fungus, protozoa, or virus. In addition to the article, information to include in the paper should include, morphology, gram stain characteristics, virulence factors, susceptibility to antibiotics, host cells, nutritional needs, growth conditions, mechanisms used to evade the immune system and invasion into the host(s), interactions with the hosts and diseases caused and affected body systems. Additionally, students should explain symptoms when the pathogen infects a host, as well as a diagnosis and the therapeutic intervention needed after infection. You may also add information on statistics related to infection (epidemiology) and any new research findings related to the pathogen.

Writing Requirements (APA format)

· Length: 2 pages (not including title page or references page)

· 1-inch margin

· Double spaced

· 12-point Times New Roman font

· Title page

· References page (minimum of 2 scholarly sources)

Grading This activity will be graded using the provided rubric.

Course Outcomes (CO): 10, 11

  

 

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MMG 404 F2015 Homework # 7

12 points

due Oct. 20, 2016

1.. A certain large population is found to exhibit a frequency of 3% for an autosomal recessive trait, i.e. 3 people out of 100, on average, have the trait (assume 100% penetrance). Assuming the alleles are in Hardy-Weinberg equilibrium, calculate the expected carrier frequency. When actually tested, it was found that the carrier frequency was 15%. Suggest one possible explanation for this non-equilibrium value.

2. a. A biallelic locus, Aa, has allele frequencies of A = 80% and a=20% in a certain population. Another biallelic locus, Bb, has allele frequencies of B = 90% and b = 10% in the same population. Both loci are found to be in Hardy-Weinberg equilibrium. Calculate the expected percentages of each of the AA, Aa, aa, BB, Bb, and bb genotypes in the population.

AA= Aa= aa=

BB= Bb= bb=

b. A recessive digenic disorder (100% penetrant) occurs ONLY when one has the aabb genotype. It’s found that 15 people out of 10,000 in this population have the disorder. What would be the expected frequency of the disorder if the Aa locus and the Bb locus were segregating independently? Is the actual frequency significantly different from this?

3. A very rare disorder is shown to depend on the genotype at three unlinked autosomal loci, A/a, B/b and C/c and that to be affected one must be homozygous for the rare allele at all three loci, that is, aabbcc. The MZ twin disorder concordance is 100%, implying that the penetrance is 100%. Calculate the expected dizygotic twin concordance for presence of the affected trait, that is, if one DZ twin shows the trait, what is the chance that the 2nd twin will be affected? (Hint: because the trait is rare, assume that both parents are heterozygous for all three loci. This is NOT the probability that both twins are affected among all DZ twin pairs.)

 

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