The Discovery Of The Gene Encoding Leptin

Our current textbooks teach us that the hypothalamus is an important integration site for adiposity and satiety signals, along with nutrients and information related to the rewarding properties of food (pleasant taste, good memories, good company). This of course was not always textbook information. Some of the earlier clues for this came from experiments by G.R. Hervey in the late 1950s. He was the first to use parabiosis to predict that a circulating factor existed that relays information on our body’s fat mass to the hypothalamus.

Parabiosis is an experimental paradigm where two animals are surgically joined in a way that they will develop a shared circulation. Factors circulating in either of the ‘parabionts’ could thus cross over into the circulatory system of the other.

The discovery of the gene encoding leptin

Our current textbooks teach us that the hypothalamus is an important integration site for adiposity and satiety signals, along with nutrients and information related to the rewarding properties of food (pleasant taste, good memories, good company). This of course was not always textbook information. Some of the earlier clues for this came from experiments by G.R. Hervey in the late 1950s. He was the first to use parabiosis to predict that a circulating factor existed that relays information on our body’s fat mass to the hypothalamus.

Parabiosis is an experimental paradigm where two animals are surgically joined in a way that they will develop a shared circulation. Factors circulating in either of the ‘parabionts’ could thus cross over into the circulatory system of the other.

Side note, such experiments, like any animal studies, are subject to tight ethical oversight where the scientific value is balanced against the degree of pain or discomfort animals experience. Obtaining approval for such parabiosis experiments today would require strong justification and could well be denied.

Hervey’s experiment started with a rat where he damaged (lesioned) the VentroMedial Hypothalamus (VMH). He then waited for some time before parabiosing this animal to a normal lean rat.

Hervey hypothesized that there existed a circulating factor (i.e. a hormone) that acted as a ‘lipostat’ by conveying information about fat mass to the VMH and that damaging the VMH would make the animal unable to respond to this factor. The VMH-lesioned animal would start to eat excessively (hyperphagia) and become morbidly obese as a consequence (think back of the girl with the craniopharyngoma). The lean parabiont however, would stop eating and die of starvation.Question: Why this is the case. Please make sure you understand this before moving on.

Experiments that suggested that the lipostat predicted from Hervey’s experiments was a single gene were done by Douglas Coleman. He maintained large colonies of mice and observed by chance (and by paying attention) that some mice in one of his colonies developed a pronounced morbid obesity phenotype, accompanied by hyperglycemia. These obese mice are infertile, but by mating the parents of offspring that developed this obese phenotype he noticed that about 1 in 4 pups developed obesity. Based on this he concluded that he was dealing with a single recessive allele that he named the obese allele (abbreviated as ob).

Around the same time but in a different colony of mice, he discovered animals that also were morbidly obese and diabetic (and could not produce offspring either). These mice too occurred in a frequency of 1 in 4 pups. He concluded that this too was a single recessive allele and he named this allele ‘diabetes’ abbreviated as db.

Based on this information, he then hypothesized that one of these alleles encoded a soluble factor while the other might encode its receptor. In order to test this hypothesis and determine which allele encoded the signal and which the receptor, Coleman carried out the following series of parabiosis experiments, with the following outcomes.

 

 

Assignment: Based on this information, explain in your own words (250 of them or more) how Coleman was able to conclude which allele encoded the signal and which the receptor.

To do so: 1. explain for each of the first three parabiosis experiments (a-c) the outcome that is described and why these experiments all pointed in the same direction. Hint: you can discuss these in any order. 2. Explain the purpose of the parabiosis experiment of the two lean mice in (d). 3. Include in your answer how Coleman was able to easily rule out before doing these parabiosis studies that the ob and db alleles with their highly similar phenotypes were two mutations of the same gene.

Note: Canvas will automatically cross-reference your submission to online sources and a comprehensive database of other papers using Turnitin. This will generate an originality report identifying whether parts of your work match or are similar to any of their sources. The work submitted will be retained as a source document in the Turnitin reference database.

 
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Philosophy Paper

Philosophy

Assignment:

Write an essay (no less than 800 words, no more than 1200) in response to the following prompt:

Both Plato a Descartes begin the process of philosophizing by worrying about the possibility of deception, and they concoct thought experiments in order to separate knowledge from mere belief and illusion. First, based on the essay we read by David Foster Wallace (This is Water”) or using Palmer’s discussions in chapter 1 and 2 tell me: why is this concern for certainty or stability a legitimate worry for the human-turned-philosopher? In other words, justify Plato’s and Descartes’ worry about the unexamined, everyday world. Second, tell me at least one significant way Plato’s and Descartes thought experiments are the same—what do they assume in common, what is their ‘rationalist’ core? And, tell me at least one significant way in which their projects differ. Third, tell me which you you think you would prefer as a method for beginning to think about the possibility of illusion or deception in your own the everyday world—escape from ‘the cave’ or purification of your ‘evil genius’? And why? Since you are already a philosopher by writing this paper, tell me: what is one practical step you could make toward that goal using this rationalist method in your current life?

 
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Energy Forms And Changes

1. After completing the background reading for this assignment, go to the “Energy Forms and Changes” simulation on the PhET simulations website at: https://phet.colorado.edu/en/simulation/energy-forms-and-changes. Click the play arrow on the simulation graphic to run the web-based simulation or click DOWNLOAD to run the simulation locally on your device.

2. Experiment with the two components of the simulation – Intro and Systems. While experimenting, think about how the concepts of forms of energy, energy transfer, and energy conversion are being illustrated in the simulation.

a. Intro Simulation – In this simulation, explore how heating or cooling iron, brick, water, and olive oil adds or removes energy from the object. Place individually, or stack, the blocks and beakers on the stands. Slide the bar to heat or cool the object(s). Visualize the types, conversion, and transfer of energy in the system by selecting Energy Symbols in the upper right of the simulation screen. Visualize the temperature change of objects by dragging thermometers (upper left of the simulation screen) to the objects.

b. Systems Simulation – In this simulation, you can build your own energy system by choosing an energy source [options (4) in the lower left of the simulation screen], an energy converter [options (2) in the center of the simulation screen], and an energy user [options (4) in the lower right of the simulation screen] and observe how various forms of energy are transferred and change within the system. Visualize the types, conversion, and transfer of energy in the system by selecting Energy Symbols. Vary the amount of energy input to the system by the energy source by using the options provided with each of the energy sources.

3. After spending some time experimenting with the simulations, follow the steps below to conduct the experiments using the Systems SimulationBefore beginning, be prepared to write down your observations.

Experiment Instructions

1. Create THREE different energy system setups to experiment with. Each setup must contain an energy source, an energy converter, and an energy user.

a. Each setup must have a different energy source and a different energy user

b. You must use different energy converters for two of the setups. (Note that there are only two types of energy converters.)

c. Before running each setup, write down a hypothesis, based on your current understanding after reading the background information for the activity, that predicts the types of energy conversions that will take place, and the transfer (flow) of energy in the system.

2. Run each of the setups by providing energy to the system from the source. Experiment with varying the rate of energy provided by the source.

3. For each system setup, tell a story of what is happening in the simulation by writing down, in very specific detail, your observations of the types of energy, transfer (flow) of energy, and conversions of energy taking place in the system as it runs. HINT: While running the simulation, select Energy Symbols to visualize the types of energy, how it is being transferred within the system, and how it is being converted from one form to another.

Address the following in recording your observations:

a. What forms of energy are contained in the energy source and the energy user?

b. What specific energy conversions are taking place within energy source and energy user?

c. What specific energy conversions are taking place within the converter as energy is transferred from the source to the user?

d. How do changes or adjustments made to the energy source affect the types, conversions, or transfer of energy within the system?

Experiment Results and Conclusions

Based on your observations for all three system set ups, formulate some general results and conclusions for:

1. how the first law of thermodynamics was obeyed in terms of accounting for all the energy in the system, and

2. how the second law of thermodynamics was obeyed in terms of the direction of energy transfer in the system.

Activity Submission

1. Create a document containing a report for your experimentation with the three system setups using these instructions:

a. For each system setup, develop a paragraph that includes:

i. a title that describes the system setup (source-converter-user)

ii. a clear and succinct presentation of your hypothesis.

iii. a clear and succinct presentation of your observations, per the instructions in part 3. of the Experiment Instructions section.

iv. a clear and succinct evaluation of the correctness of your hypothesis based on the information presented in part iii above.

b. Develop a paragraph that includes a clear and succinct presentation of your general results and conclusions, per the instructions in the Experiment Results and Conclusions section above.

c. Include your full name and the date you completed the activity at the top of the document.

Submit your document (in either .docx or .pdf file format) as instructed in the assignment location within the Canvas course

EDS 1021

Week 6 Interactive Activity

Radioactive Dating Game

 

Objective

Using a simulation, apply the scientific method to investigate radioactive decay and its application to radiometric dating.

Background Reading

Before attempting the activity, review the topics Half-Life, Radiometric Dating, and Decay Chains in Chapter 12 of The Sciences.

Introduction to the Simulation

1. After completing the background reading for this assignment, go to the “Radioactive Dating Game” simulation on the PhET simulations website at: http://phet.colorado.edu/en/simulation/radioactive-dating-game. Click the play arrow on the simulation graphic to run the web-based simulation or click DOWNLOAD to run the simulation locally on your device.

Simulation requirements: This interactive simulation is optimized for use on computers (MACs or PCs) and may not run on some tablets, notebooks, cell phones, or other devices. Running the simulation will require an updated version of  Java  software (free). If you do not or are not sure if you have Java on your computer, go to  the Java Website . If you cannot get the simulation to run, consult The PhET Simulation Troubleshooting Guide on the course website.

2. Explore and experiment on the four different tabs (areas) of the simulation. While experimenting, think about how the concepts of radioactive decay are being illustrated in the simulation.

 

a. Half-Life tab – Observe a sample of radioactive atoms decaying – carbon-14, uranium-238, or ? (a custom-made radioactive atom). Clicking on the add 10 button adds 10 atoms at a time to the decay area. There are 100 atoms in the bucket; so, clicking the add 10 button 10 times empties the bucket into the decay area. Observe the pie chart and time graph as atoms decay. You can pause or step the simulation as atoms decay, and Reset the simulation, using buttons at the bottom of the screen.

b. Decay Rates tab – Similar to the half-life tab, but different! Atom choices are carbon-14 and uranium-238. The bucket has a total of 1,000 atoms. Drag the slide bar on the bucket to the right to increase the number of atoms added to the decay area. Observe the pie chart and time graph as atoms decay. Note that the graph for the Decay Rates tab provides different information than the graph for the Half-Life tab. You can pause or step the simulation as atoms decay, and Reset the simulation, using buttons at the bottom of the screen.

c. Measurement tab – Use a probe to virtually measure the amount of radioactive material within an object or in the atmosphere. The probe can be set to detect the decay of either carbon-14 or uranium-238 atoms. Follow prompts on the screen to run a simulation of a tree growing and dying, or of a volcano erupting and creating a rock, and then measuring the decay of atoms within each object.

d. Dating Game tab – Use a probe to virtually measure the percentage of radioactive atoms remaining within various objects and estimate the ages of objects by applying the concept of half-life. The probe can be set to either detect carbon-14, uranium-238, or other “mystery” elements that may be contained in the objects. Drag the probe over an object, select which element to measure, and then slide the arrow on the graph to match the percentage of atoms measured by the probe. The time (t) shown for the matching percentage can then be entered as the estimate in years of the object’s age.

e. Pause button ( I I ) – Simulation is running when this is showing; press to pause the simulation.

f. Play arrow ( > ) – Simulation is paused when this is showing; press to run the simulation.

 

3. After getting oriented to the simulation, follow the steps below to perform four different experiments. Before beginning, be prepared to write down hypotheses and observations for the experiments.

Experiments

 

Experiment 1: Half-Life

In this experiment, you will visualize the radioactive decay of atoms and investigate the concept of half-life.

Before completing the experiment, write down a hypothesis, based on your current understanding, that makes specific predictions for how the decay of a radioactive substance will progress over time.

1. Experiment setup: click on the Half-Life tab at the top of the simulation screen.

2. Experiment procedure:

Construct a table like the one below. Complete the following steps for parts I and II of the experiment to complete the table.

Part I – Carbon-14

a. Make sure that Carbon-14 is selected in the Choose Isotope box. Click the pause button ( I I ) at the bottom of the screen so that it shows the play arrow ( > ). Click the Add 10 button below the Bucket o’ Atoms ten times to empty the bucket and place 100 carbon-14 atoms in the decay area.

b. The half-life of carbon-14 is about 5,700 years. Based on the definition of half-life, if you left these 100 carbon-14 atoms to sit around for 5,700 years, what would you predict to be the number of carbon-14 atoms that would radioactively decay during that time? Write your answer down.

c. Click the play arrow. As the simulation runs, carefully observe what is happening to the carbon-14 atoms in the decay area, and the graphs at the top of the screen (both the pie chart and the time graph).

d. After all atoms have decayed, click the pause button, and the Reset All Nuclei button in the decay area.

e. Repeat steps c and d until you have a good idea of what is going on. Then, write down a specific description of what you observed happening, both in the decay area and on the pie chart and time graph, while the simulation is in play mode.

f. Repeat step c again, but this time, watch the graph at the top of the window carefully, and click “pause” when Time reaches 5,700 years, i.e., when the carbon-14 atom moving across the graph reaches the dashed line labeled Half-Life . If you don’t pause the simulation on or very close to the dashed line, click the Reset All Nuclei button and repeat step c again.

g. Once you have paused the simulation in the correct spot, record the number of carbon-14 nuclei that have decayed into nitrogen-14 (the number next to #14N, to the left of the pie chart).

h. Click the Reset All Nuclei button in the decay area.

i. Repeat steps f through h for two more trials, to record a total of three values for step g.

 

Part II – Uranium-238

a. Click Reset All below the Choose Isotope box, then yes in the box that pops up. Click on the radio button for Uranium-238 in the Choose Isotope box. Click the pause button at the bottom of the screen so that it shows the play arrow. Click the Add 10 button ten times to empty the bucket and place 100 Uranium-238 atoms in the decay area.

b. The half-life of Uranium-238 is 4.5 billion years!* Based on the definition of half-life, if you left these 100 Uranium-238 atoms to sit around for 4.5 billion years, write down your prediction of the number of Uranium-238 atoms that will radioactively decay over that time.

c. Click the play arrow. Watch the graph at the top of the window carefully, and click pause when Time reaches 4.5 billion years, i.e., when the Uranium-238 atom moving across the graph reaches the dashed line labeled Half Life. If you don’t pause the simulation on or very close to the dashed line, click the Reset All Nuclei button and repeat step c.

d. Once you have paused the simulation in the correct spot, record the number of Uranium-238 nuclei that have decayed into Lead-206 (the number next to #206Pb to the left of the pie chart).

e. Click the Reset All Nuclei button in the decay area.

f. Repeat steps c through e for two more trials, to record a total of three values for step d.

 

Radioactive

Element

Number of atoms in the sample at Time = 0 Prediction of # atoms that will decay when time reaches one half-life Number of atoms that have decayed when

Time = Half Life

      Trial #1 Trial #2 Trial #3
Carbon-14 100        
Uranium-238 100        

 

 

Experiment 1 – Results and Conclusions

1. In Part I of the experiment (and in nature), carbon-14 radioactively decays to nitrogen-14. Based on what you read in Chapter 12 of The Sciences about the three types of radioactive decay, name the specific type of radioactive decay taking place in Part I of the experiment.

2. Based on your observations and data collected while conducting Experiment 1:

a. Formulate a written discussion that describes the nature of radioactive decay – i.e., is the process random, exact, or something else, and can you make any analogies between radioactive decay and other processes you observe in your everyday life?

b. Does the data collected in parts I and II of the experiment validate or negate the concept of radioactive half-life? Support this conclusion by formulating a written comparison between your predictions from step b for the number of atoms that will radioactively decay over one half-life and the values you recorded in the trials.

* Unlike carbon-14, which undergoes only one radioactive decay to reach the stable nitrogen-14, uranium-238 undergoes many decays into many intermediate unstable elements before finally getting to the stable element lead-206. (See the decay chain for uranium-238 in Chapter 12 for details).

 

Experiment 2: Decay Rates

In this experiment, you will again visualize the radioactive decay of atoms, and you will also make some additional quantitative measurements of the decay. Your hypothesis from Experiment 1 also applies to this experiment.

1. Experiment setup: click on the Decay Rates tab at the top of the simulation screen.

2. Experiment procedure:

Construct a table like the one below. Complete the following steps for parts I and II of the experiment to complete the table.

Part I – Carbon-14

a. Click the Reset All button below the Choose Isotope box.

b. In the Choose Isotope area, click the button next to carbon-14.

c. Drag the slide bar on the bucket of atoms all the way to the right. This will put 1,000 radioactive nuclei into the decay area. When you let go of the slide bar, the simulation will start right away. Watch the graph at the bottom of the screen until all atoms have decayed.

d. From the graph, record the percentage of carbon-14 nuclei remaining at times equivalent to 1, 2, and 3 half-lives of carbon-14 (a total of three percentage values). Recall that the half-life of Carbon-14 is about 5700 years.

 

Part II – Uranium-238

a. In the Choose Isotope area on the right side of the screen, click the button next to Uranium-238.

b. Repeat step c of Part I for uranium-238.

c. From the graph, record the percentage of uranium-238 nuclei remaining at times equivalent to 1, 2, and 3 half-lives of uranium-238 (a total of three percentage values). Recall that the half-life of uranium-238 is about 4.5 billion years.

 

Radioactive

Element

Percentage of the element remaining after:
  1 half-life 2 half-lives 3 half-lives
Carbon-14      
Uranium-238      

 

 

Experiment 2 – Results and Conclusions

Does the data collected in parts I and II of the experiment validate or negate the concept of radioactive half-life? Support this conclusion by discussing the trends in the number of radioactive nuclei remaining after 1, 2, and then three half-lives had passed.

 

Experiment 3: Measurement

In this experiment, you will use a probe to detect the decay of radioactive material within a rock and a tree.

Before completing the experiment, write down a hypothesis, based on your current understanding, that predicts how the simulation should be utilized to detect each object’s age.

1. Experiment setup: click on the Measurement tab at the top of the simulation screen.

2. Experiment procedure:

Part I – Tree

a. Under Choose an Object, click on the button for Tree. In the Probe Type box, click on the buttons for Carbon-14, and Objects. This sets up a probe to measure radioactive decay of any carbon-14 in the tree. Note that the probe can only detect the element for which it is set.

b. Click Plant Tree at the bottom of the screen. As the simulation runs, observe that the tree grows and lives for about 1,200 years, then dies and begins to decay. Observe the probe reading (upper left box) and graph (upper right box) at the top of the screen showing the percentage of carbon-14 in the tree over time. Write down your observations of what is taking place in the visual scenario, the probe reading, and the graph.

c. Click either of the two Reset buttons on the screen. In the Probe Type box, set the probe to measure uranium-238 instead of carbon-14. So, now the probe is detecting the decay of any uranium-238 in the tree.

d. Click Plant Tree and again observe the probe reading and graph as the simulation runs. Write down your observations of the probe reading and graph.

 

Part II – Volcanic Rock

a. Click either of the two Reset buttons on the screen.

b. Under Choose an Object, click the button for Rock. Keep the probe type set on Uranium-238.

c. Click Erupt Volcano and observe the volcano creating and ejecting very hot igneous rocks. As the simulation runs, observe the probe reading and graph showing the percentage of uranium-238 in the rock over time. Write down your observations of what is taking place in the visual scenario, the probe reading, and the graph.

d. Click either of the two Reset buttons on the screen. In the Probe Type box, set the probe to measure the decay of carbon-14 instead of uranium-238. So, now the probe is detecting the decay of carbon-14 in the rock.

e. Click Erupt Volcano and again observe the probe reading and graph as the simulation runs. Write down your observations of the probe reading and graph.

 

Answer questions 1–5 below to help you formulate some results and conclusions for this experiment. You may need to do some additional experimentation to answer the questions.

1. Explain what happened when the probe was used to measure uranium-238 in the tree and carbon-14 in the rock.

2. At what point in the simulation does the probe detect a decrease in the carbon-14 in the tree? Explain why this is the case.

3. At what point in the simulation does the probe detect a decrease in uranium-238 in the rock? Explain why this is the case.

4. When the amount of carbon-14 in the tree has decreased to 50 percent, approximately how many years have passed since the tree died?

5. When the amount of uranium-238 in the rock has decreased to 50 percent, approximately how many years have passed since the volcano erupted?

 

Experiment 3 – Results and Conclusions

Formulate a written conclusion for how the probes in the simulation should be properly utilized to detect the ages of each object. Support your conclusion with your observations while conducting the experiment and answers to the above questions.

 

Experiment 4: Dating Game

In this experiment, you will determine the age of various objects using a probe that can be set to detect the radioactive decay of various elements. Your hypothesis from Experiment 3 also applies to this experiment.

1. Experiment setup: Click on the Dating Game tab at the top of the simulation screen. Verify that the Objects button is clicked below the Probe Type box.

2. Experiment procedure:

Construct a table like the one below. Complete the following steps to complete the table:

a. Set the Probe Type to either Carbon-14 or Uranium-238, as appropriate for the object you are measuring, based on your findings in Experiment 3.

b. Drag the probe directly over the object. The box in the upper left, above Probe Type, will show the percentage of the radioactive element that remains in the item, based on the level of radioactivity being detected by the probe.

c. Drag the green arrow on the graph to the right or left, until the percentage in the box on the graph matches the percentage of element in the object. Once you have the arrow positioned correctly, enter – in the Estimate the age… box – the time (t) shown, as the estimate for the age of the rock or fossil. Click Check Estimate to see if your estimate is correct.

 

Practice completing the above steps using this example:

1) Let’s determine the age of the dead tree. Since this is a once-living thing, set the Probe Type to Carbon-14.

2) Drag the probe over of the tree, and then look at the probe reading: it detects 97.4% of carbon-14 remaining in the dead tree.

3) Drag the green arrows on the graph to the right or left until you land on a carbon-14 percentage of 97.4%, matching the reading from the probe. When the graph reads 97.4%, it shows that time (t) equals 220 years.

4) Type “220” into the box that says Estimate age of dead tree: and click Check Estimate. You should see a green smiley face, indicating that you have correctly figured out the age of the dead tree, 220 years. This means that the tree died 220 years ago.

 

TIPS:

· The estimate for the age of an object must be entered in years. So, if t = 134.8 MY on the graph, which means 134.8 million years, you would enter the number 134,800,000 as the estimate in years for the age of a rock. The estimates do not have to be exact to be registered as correct, but it must be close. For example, if 134,000,000 were entered for the above example, the simulation would return a green smiley face for a correct estimate

· For the items on the list marked with an *, you should discover that neither carbon-14 nor uranium-238 will work to determine the item’s age. Select Custom for the Probe Type, and experiment to find an element from the drop-down menu that returns a probe reading other than 0.0%. Note that for each of the Custom elements, only the half-life of the element is given, not the name of the element

Object Being Measured Element Detected to Determine Age Age (Years)
Animal skull    
House    
Living tree    
Dead tree    
Bone    
Wooden cup    
Large human skull    
Fish bones    
Rock 1    
Rock 3    
Rock 5    
Fish fossil*    
Dinosaur skull*    
Trilobite*    
Small human skull    

Answer questions 1–5 below to help you formulate some results and conclusions for this experiment. You may need to do some additional experimentation to answer the questions.

1. Explain the differences in carbon-14 readings in the living tree versus the dead tree.

2. Explain why some of the items detect carbon-14 and not uranium-238, and vice-versa.

3. Explain why the probe could not detect carbon-14 or uranium-238 in the fish fossil, dinosaur skull, or trilobite, but could detect one of the Custom elements in each of those items.

4. Explain why the probe detected uranium-238 in Rocks 1, 3, and 5, but the probe detected the Custom 100 my element in only Rocks 1 and 3, and not Rock 5?

5. Explain why the probe set to Carbon-14 gives a reading of 100% in the living trees.

Experiment 4 – Results and Conclusions

1. Based on your observations while conducting the experiment and your answers to the questions above, formulate a written discussion that explains how to properly use the simulation to determine the age of:

A. The rocks

B. The items that contain once-living material

2. Include in your explanation which element the probe should be set to and why, and how to use the slider on the graph to determine the age.

Activity Submission

1. Create a document containing a report for each experiment. Your document should contain four paragraphs, one for each experiment.

a. Title each paragraph with the corresponding name for each experiment, as it is stated in the headings for the experiments above (e.g., Experiment 1: Half-Life).

b. For each experiment report:

i. Clearly and succinctly present your hypothesis for the experiment.

ii. Based on the information prompted for in the experiment’s Procedure and Results and Conclusions section, clearly and succinctly summarize your observations, results, and conclusions for the experiment, and include any data collected and calculations made.

iii. Clearly and succinctly evaluate the correctness of your hypothesis based on the information presented in part ii above.

c. Include your full name and the date you completed the activity at the top of the document.

 

2. Submit your document (in either .docx or .pdf file format) as instructed in the assignment location within the Canvas course.

 
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Understanding Of APA Formatting Conventions

Develop: Understanding of APA Formatting Conventions
Evaluation Title: APA Formatting: You’re the Instructor
Let’s imagine you are a college instructor! Congratulations! Now it’s time to get to work.
McStudent 1

Information Literacy Skills in the College Classroom

Student McStudent

Herzing University

EN 111: Information Literacy

Professor Smith

April 27, 2020

McStudent 2

Introduction

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First Level Heading

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McStudent 3

BIBLIOGRAPHY

Hanson, L. F. (2018). Fundamentals of information literacy. Journal of Library Studies, 55(11), 893-896.

http://doi.org/gh6ty8

Alvarez, Juan, and Julio A. Camargo. (2016, Jan). “Undergraduate Perception of Information Literacy:

Defining, Attaining and Self-Assessing Skills.” College & Research Libraries, vol. 21, no. 1, pp. 90-

94. https://doi.org/11.1342/rev0000128
Explain each error in a numbered list, using full sentences for each.

After you complete your assignment in a Word document, save your work, and then you will need to attach the completed document to your submission. The process will be similar to making an attachment to an e-mail:

Click Submit Assignment (upper right corner)
Under Attach File, click on “Browse My Computer.”
Look up your saved document, and click “Open.”
Click “Submit.”
Your assignment submission should be a Word document that fully adheres to the instructions listed above. Be sure to proofread your assignment.

 
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