necrotizing fasciitis

Comment 1


Mucor reminds me of necrotizing fasciitis which is caused by a bacteria rather than a fungus.  In addition to surgical debridement and bronchoscopy it is recommended patients receive a MRI because they“can demonstrate soft tissue lesions better than CT scan(Mohammadi et al., 2014).  This will allow the healthcare team to monitor the progress of the treatment.


Comment 2


our post subject description covers multiple aspects of Mucus and immunocompromising conditions as the main risk factor for mucormycosis. You also indicated that patients with uncontrolled diabetes mellitus, especially those with ketoacidosis, are also at high risk. I will add that other risk-factors for the development of mucormycosis are ketoacidosis (diabetic or other), iatrogenic immunosuppression, use of corticosteroids or deferoxamine, disruption of mucocutaneous barriers by catheters and other devices, and exposure to bandages contaminated by these fungi. Mucus is a very dangerous virus, as it invades deep tissues via inhalation of airborne spores, percutaneous inoculation or ingestion. Probable diagnosis of mucormycosis requires the combination of various clinical data and the isolation in culture of the fungus from clinical samples; and treatment of mucormycosis requires a rapid diagnosis, correction of predisposing factors, surgical resection, debridement and appropriate antifungal therapy.


Comment 3


In the medscape article I noted I found that in most of the Mucor cases the patient had risk factors such as diabetic ketoacidosis  and neutropenia were present. Since that is our discussion I highlighted this. It was also interesting to look at pediatric cases of Mucor in a related article. In this article, “pediatric mucormycosis was reviewed, such as infection involving immunosuppressed children; this disease has also been observed in neonates (especially premature infants), patients with burns, and children with a history of incidental trauma.”  the article did not mention Diabetic ketoacidosis. (Varman, 2017)

 
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